BREAKING BIOLOGICAL BARRIERS
09:00 Engineering Smarter Vectors To Revolutionize Precision Delivery Of Genetic Therapies With Unmatched Specificity And Clinical
Impact.

• Explore the next frontier in genetic medicine: precision delivery of therapeutic payloads to specific cells and tissues.
• Discuss cutting-edge strategies in vector engineering to overcome biological delivery barriers.
• Highlight approaches that enhance specificity, efficiency, and safety in genetic therapy delivery.
• Provide insights into the rational design of next generation viral and non-viral vectors.
• Showcase tailored delivery systems for a broad range of therapeutic applications.
• Emphasize translational breakthroughs bridging the gap from bench to bedside. 
• Present how smarter vector systems are enabling more effective and clinically impactful gene therapies.

09:25 Questions & Discussion
 

BEYOND IMMUNITY
09:30 REDUCING HOST RESPONSES WHILE ENHANCING DELIVERY IN VIRAL GENE THERAPY PLATFORMS
Viral gene therapy has emerged as a promising avenue for the treatment of a variety of genetic disorders. However, the success of these therapies often hinges on two critical challenges: the immune responses of the host and the efficiency of viral delivery systems. This talk will delve into innovative strategies designed to reduce host immune responses to viral vectors while simultaneously enhancing their ability to effectively deliver genetic material to targeted cells. Key areas of focus include:

• Exploration of genetic modifications and novel viral platform designs aimed at minimizing immune recognition and improving vector stability and specificity.
• Discussion on advancements in vector delivery techniques, such as tissue-specific targeting and controlled release, to increase the therapeutic efficacy of gene therapies.
• Examination of current clinical trials and preclinical research that showcase these advancements, along with a forward-looking perspective on overcoming remaining obstacles.

09:55 Questions & Discussion
 

ADVANCING CRISPR-CAS9 PRECISION PANEL DISCUSSION
10:00 CRISPR Under the Microscope: Innovations for Precision and Safety in Genome Editing

• Navigating the Precision and Pitfalls of CRISPR-CAS9: Addressing Off-Target Effects in Genome Editing. 

CRISPR-Cas9 revolutionizes gene editing with unprecedented precision, but off-target effects remain a critical challenge. This talk explores strategies to enhance specificity, ensuring safer, more effective applications in medicine and biotechnology. 

• Off-Target Effects in CRISPR: A Critical Barrier to Reliable Therapeutic and Agricultural Applications. 

This talk explores the significance of off-target effects in CRISPR technology, discussing their impact on both therapeutic interventions and agricultural advancements. We’ll examine current challenges, potential risks, and strategies for improving precision. 

• Unveiling Off-Target Modifications: Advancing CRISPR Safety in Medicine. 

Understanding off-target modifications is crucial for enhancing CRISPR's safety. Investigating unintended modifications requires exploring the mechanisms driving off-target effects to improve precision and reduce risks. 

• Enhancing CRISPR Precision and Safety: Strategies for Detecting and Mitigating Off-Target Effects with Novel Cas9 Variants and Computational Algorithms 

This session offers an in-depth look at the latest strategies aimed at improving CRISPR technology by detecting and mitigating off-target effects. We will discuss novel Cas9 variants and computational algorithms crucial for reducing unintended genetic modifications, ensuring safer gene editing. 

• Enhancing Precision: The Future of CRISPR Technology in Genetic Engineering 

Advancements in CRISPR technology are significantly improving its accuracy, reducing off-target effects, and advancing safer genetic engineering practices. Future innovations aim to refine specificity, paving the way for broader, more reliable applications in medicine.

 11:15 Questions & Discussion 

11:30 Refreshment Break

PANEL DISCUSSION ON CAR-T and TCR-T THERAPIES
12:00 Enhancing CAR-T and TCR-T Therapies in Solid Tumors: Clinical Insights on Personalization, Combination Approaches, and Translational Hurdles

• Advancing Clinical Strategies for CAR-T and TCR-T Cell Therapies in Solid Tumors: Overcoming Challenges and Enhancing Efficacy
• CAR-T and TCR-T Cell Therapies in Solid Tumors: Navigating Safety, Persistence, and Tumor Microenvironment Challenges in Clinical Trials
• Optimizing CAR-T and TCR-T Cell Therapies: Lessons from Clinical Trials and Future Directions for Solid Tumor Treatment 
• Personalizing CAR-T and TCR-T Therapies for Solid Tumors: Biomarkers, Combination Strategies, and Clinical Translation Challenges

12:25 Questions & Discussion
 

OVERCOMING VARIABILITY
12:30 Scalable Manufacturing Strategies For Cell Based Therapies To Achieve Quality, Affordability, And Regulatory Excellence In Advanced Bioproduction

Scaling the production of cell-based therapies poses significant technological and economic challenges. Ensuring consistent quality across batches is difficult due to inherent product variability. This talk explores innovative strategies to enhance manufacturing scalability while maintaining rigorous quality control, addressing key hurdles in standardization, cost-efficiency, and regulatory compliance in advanced therapeutic production.
 

12:55 Questions & Discussion
 

13:00 Lunch Break